What can result from the prolonged use of topical corticosteroids for treating lichen planus?

Prolonged use of topical corticosteroids can lead to iatrogenic candidiasis, which is an overgrowth of the Candida fungus due to the immunosuppressive effects of corticosteroids. These medications can alter the local immune response in the mucosal tissues, creating an environment conducive to fungal infections. In the case of lichen planus, which is often treated with topical corticosteroids to reduce inflammation and alleviate symptoms, the extended use of these agents can disrupt the natural balance of microorganisms, allowing pathogens like Candida to proliferate.

While corticosteroids are effective in controlling symptoms of inflammatory conditions, it is important to monitor for potential complications such as iatrogenic candidiasis. Other complications, like hyperglycemia or osteoporosis, are more commonly associated with systemic corticosteroid use rather than localized applications. Similarly, bacterial infections may arise in compromised areas but are not a specific or primary outcome related to the use of topical corticosteroids in lichen planus treatment. Understanding the balance between the benefits and risks of corticosteroid therapy is crucial in managing conditions like lichen planus.