Which category of drugs is NOT associated with gingival enlargement?

The category of drugs that is not associated with gingival enlargement is MAO inhibitors. Gingival enlargement, or gingival hyperplasia, is a condition characterized by an overgrowth of gum tissue, and it is typically linked to specific medications.

Anticonvulsants, such as phenytoin, are well-documented for causing gingival enlargement as a side effect. This can result from their effect on the proliferation of fibroblasts, leading to increased collagen deposition in the gingival tissue.

Immunosuppressants, like cyclosporine, are also known to contribute to gingival hyperplasia due to their influence on cellular growth and immune response, promoting gingival tissue overgrowth.

Calcium channel blockers, commonly prescribed for hypertension and other cardiovascular conditions, such as nifedipine and amlodipine, can lead to gingival overgrowth as well. They affect the calcium ion concentration in heart and smooth muscle tissues and also play a role in gingival fibroblast activity, leading to an overproduction of the connective tissue.

In contrast, MAO inhibitors, used primarily in the treatment of depression and anxiety, do not have a direct link to gingival enlargement. Their mechanism of action focuses on increasing neurotransmitter levels